Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

Abstract The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus . Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence. Here, we show that Agd3 deacet...

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Библиографические подробности
Главные авторы: Natalie C. Bamford, François Le Mauff, Jaime C. Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell
Формат: Artigo
Язык:английский
Опубликовано: 2020
Online-ссылка:https://doi.org/10.1038/s41467-020-16144-5
https://www.nature.com/articles/s41467-020-16144-5.pdf
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https://doi.org/10.1038/s41467-020-16144-5
https://www.nature.com/articles/s41467-020-16144-5.pdf

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