A conserved and regulated mechanism drives endosomal Rab transition
Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation, Rab5 is replaced by Rab7, though the underlyi...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2020
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| Online Access: | https://doi.org/10.7554/elife.56090 |
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