Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Abstract Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Inst...

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Main Authors: Jay Daniels, Peter Doukas, Maria E. Martínez Escala, Kimberly G. Ringbloom, David Shih, Jingyi Yang, Kyle Tegtmeyer, Joonhee Park, Jane Joy Thomas, Mehmet Emrah Selli, Can Altunbulakli, Ragul Gowthaman, Samuel Mo, Balaji Jothishankar, David R. Pease, Barbara Pro, Farah Abdulla, Christopher R. Shea, Nidhi Sahni, Alejandro A. Gru, Brian G. Pierce, Abner Louissaint, Joan Guitart, Jaehyuk Choi
Format: Artigo
Language:English
Published: 2020
Online Access:https://doi.org/10.1038/s41467-020-15572-7
https://www.nature.com/articles/s41467-020-15572-7.pdf
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https://doi.org/10.1038/s41467-020-15572-7
https://www.nature.com/articles/s41467-020-15572-7.pdf

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