Structure of the human BBSome core complex

The BBSome is a heterooctameric protein complex that plays a central role in primary cilia homeostasis. Its malfunction causes the severe ciliopathy Bardet-Biedl syndrome (BBS). The complex acts as a cargo adapter that recognizes signaling proteins such as GPCRs and links them to the intraflagellar...

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Auteurs principaux: B.U. Klink, Christos Gatsogiannis, Oliver Hofnagel, Alfred Wittinghofer, Stefan Raunser
Format: Artigo
Langue:anglais
Publié: 2020
Accès en ligne:https://doi.org/10.7554/elife.53910
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