Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Abstract The negative regulator of p53, MDM2, is frequently overexpressed in acute myeloid leukemia (AML) that retains wild-type TP53 alleles. Targeting of p53-MDM2 interaction to reactivate p53 function is therefore an attractive therapeutic approach for AML. Here we show that an orally active inhi...

Fuld beskrivelse

Saved in:
Bibliografiske detaljer
Main Authors: Yasutaka Hayashi, Susumu Goyama, Xiaoxiao Liu, Moe Tamura, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, Satoshi Yamazaki, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Koichi Matsuda, Goro Sashida, Hitoshi Takizawa, Toshio Kitamura
Format: Artigo
Sprog:engelsk
Udgivet: 2019
Online adgang:https://doi.org/10.1038/s41467-019-12555-1
https://www.nature.com/articles/s41467-019-12555-1.pdf
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Internet

https://doi.org/10.1038/s41467-019-12555-1
https://www.nature.com/articles/s41467-019-12555-1.pdf

Lignende værker