Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing
Rationale: Mutations of SLC26A4 that abrogate pendrin, expressed in endolymphatic sac, cochlea and vestibule, are known to cause autosomal recessive sensorineural hearing loss with enlargement of the membranous labyrinth.This is the first study to demonstrate the feasibility of gene therapy for pend...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2019
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| On-line přístup: | https://doi.org/10.7150/thno.38032 |
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