YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

Abstract YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and the resulting tumors share histo-molecular characteristics...

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Huvudupphovsmän: Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, Patricia B. G. Silva, Mikaella Vouri, Lei Zhang, Sebastian Brabetz, Laura Sieber, Melissa Gulley, Monika Mauermann, Tatjana Wedig, Norman Mack, Yuka Imamura Kawasawa, Tanvi Sharma, Marc Zuckermann, Felipe Andreiuolo, Eric C. Holland, Kendra K. Maaß, Huiqin Körkel-Qu, Hai‐Kun Liu, Felix Sahm, David Capper, Jens Bunt, Linda J. Richards, David Jones, Andrey Korshunov, Lukas Chávez, Peter Lichter, Mikio Hoshino, Stefan M. Pfister, Marcel Kool, Wei Li, Daisuke Kawauchi
Materialtyp: Artigo
Språk:engelska
Publicerad: 2019
Länkar:https://doi.org/10.1038/s41467-019-11884-5
https://www.nature.com/articles/s41467-019-11884-5.pdf
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https://doi.org/10.1038/s41467-019-11884-5
https://www.nature.com/articles/s41467-019-11884-5.pdf

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