Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans express three genetic ApoE variants, ApoE2, ApoE3, and ApoE4, which exhibit distinct ApoE receptor-binding properties and diff...

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Hlavní autoři: Yu‐Wen Alvin Huang, Bo Zhou, Amber M. Nabet, Marius Wernig, Thomas C. Südhof
Médium: Artigo
Jazyk:angličtina
Vydáno: 2019
On-line přístup:https://doi.org/10.1523/jneurosci.2994-18.2019
https://www.jneurosci.org/content/jneuro/39/37/7408.full.pdf
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