Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans express three genetic ApoE variants, ApoE2, ApoE3, and ApoE4, which exhibit distinct ApoE receptor-binding properties and diff...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2019
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| Online Access: | https://doi.org/10.1523/jneurosci.2994-18.2019 https://www.jneurosci.org/content/jneuro/39/37/7408.full.pdf |
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