Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from...

Szczegółowa specyfikacja

Zapisane w:

Opis bibliograficzny
Główni autorzy:	Josepmaria Argemí, María U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquín Cabezas, Juan José Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan Pablo Arab, Meritxell Ventura‐Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Òdena, Juan L. Gómez, Tomás Aragón, José Altamirano, Juan Caballería, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho‐Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark Thursz, Jelena Mann, Matías A. Ávila, Ramón Bataller
Format:	Artigo
Język:	angielski
Wydane:	2019
Dostęp online:	https://doi.org/10.1038/s41467-019-11004-3 https://www.nature.com/articles/s41467-019-11004-3.pdf
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
od: Argemi, Josepmaria, i wsp.
Wydane: (2019)

Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension
od: Chen, Jiegen, i wsp.
Wydane: (2020)

Identifying New Epigenetic Drivers of Liver Fibrosis
od: Argemi, Josepmaria, i wsp.
Wydane: (2018)

Hepatocyte–stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids
od: Argemi, Josepmaria, i wsp.
Wydane: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
od: Massey, Veronica, i wsp.
Wydane: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
od: Veronica Massey, i wsp.
Wydane: (2020)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
od: Marin, Veronica, i wsp.
Wydane: (2017)

Systemic Inflammatory Response and Serum Lipopolysaccharide Levels Predict Multiple Organ Failure and Death in Alcoholic Hepatitis
od: Michelena, Javier, i wsp.
Wydane: (2015)

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis
od: Javier Michelena, i wsp.
Wydane: (2015)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
od: V. Marin, i wsp.
Wydane: (2017)

A novel mouse model of acute-on-chronic cholestatic alcoholic liver disease: A systems biology comparison with human alcoholic hepatitis
od: Furuya, Shinji, i wsp.
Wydane: (2019)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
od: Brandl, Katharina, i wsp.
Wydane: (2018)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
od: Katharina Brandl, i wsp.
Wydane: (2018)

Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis
od: Gao, Bei, i wsp.
Wydane: (2021)

Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis
od: Mohamed Bou Saleh, i wsp.
Wydane: (2021)

Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis
od: Lang, Sonja, i wsp.
Wydane: (2019)

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis
od: Sonja Lang, i wsp.
Wydane: (2019)

Alcoholic Hepatitis
od: Gougol, Amir, i wsp.
Wydane: (2021)

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
od: Pau Sancho‐Bru, i wsp.
Wydane: (2012)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
od: Aguilar-Bravo, Beatriz, i wsp.
Wydane: (2019)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
od: Beatriz Aguilar‐Bravo, i wsp.
Wydane: (2018)

Loss of liver function in chronic liver disease: An identity crisis
od: Carmen Berasain, i wsp.
Wydane: (2022)

Perturbations in mitochondrial dynamics are closely involved in the progression of Alcoholic Liver Disease.
od: Palma, Elena, i wsp.
Wydane: (2020)

TLR7‐let‐7 Signaling Contributes to Ethanol‐Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis
od: Massey, Veronica L., i wsp.
Wydane: (2018)

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases
od: Guldiken, Nurdan, i wsp.
Wydane: (2021)

Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
od: Dubuquoy, Laurent, i wsp.
Wydane: (2009)

Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
od: Stärkel, Peter, i wsp.
Wydane: (2019)

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
od: Odena, Gemma, i wsp.
Wydane: (2016)

Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming
od: Beatriz Aguilar‐Bravo, i wsp.
Wydane: (2023)

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH
od: Zanieri, Francesca, i wsp.
Wydane: (2020)

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis
od: Morales-Ibanez, Oriol, i wsp.
Wydane: (2015)

Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis
od: Rachakonda, Vikrant, i wsp.
Wydane: (2019)

Intestinal virome in patients with alcoholic hepatitis
od: Jiang, Lu, i wsp.
Wydane: (2020)

Intestinal Virome in Patients With Alcoholic Hepatitis
od: Lu Jiang, i wsp.
Wydane: (2020)

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease
od: Ratna, Anuradha, i wsp.
Wydane: (2021)

504. Case SEries: Nasal Antimicrobial Photodisinfection (APDT) as Treatment Protocol for Asymptomatic and Early Stage COVID-19 Patients
od: Kolenda, Jack, i wsp.
Wydane: (2021)

Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
od: Meritxell Ventura‐Cots, i wsp.
Wydane: (2022)

Alcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder
od: Juan Pablo Arab, i wsp.
Wydane: (2023)

Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD
od: Edilmar Alvarado‐Tápias, i wsp.
Wydane: (2023)

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems
od: Alejandro Soto–Gutiérrez, i wsp.
Wydane: (2017)