Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from...

保存先:

書誌詳細
主要な著者:	Josepmaria Argemí, María U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquín Cabezas, Juan José Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan Pablo Arab, Meritxell Ventura‐Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Òdena, Juan L. Gómez, Tomás Aragón, José Altamirano, Juan Caballería, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho‐Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark Thursz, Jelena Mann, Matías A. Ávila, Ramón Bataller
フォーマット:	Artigo
言語:	英語
出版事項:	2019
オンライン･アクセス:	https://doi.org/10.1038/s41467-019-11004-3 https://www.nature.com/articles/s41467-019-11004-3.pdf
タグ:	タグ追加タグなし, このレコードへの初めてのタグを付けませんか!

類似資料

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
著者:: Argemi, Josepmaria, 等
出版事項: (2019)

Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension
著者:: Chen, Jiegen, 等
出版事項: (2020)

Identifying New Epigenetic Drivers of Liver Fibrosis
著者:: Argemi, Josepmaria, 等
出版事項: (2018)

Hepatocyte–stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids
著者:: Argemi, Josepmaria, 等
出版事項: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
著者:: Massey, Veronica, 等
出版事項: (2020)

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis
著者:: Veronica Massey, 等
出版事項: (2020)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
著者:: Marin, Veronica, 等
出版事項: (2017)

Systemic Inflammatory Response and Serum Lipopolysaccharide Levels Predict Multiple Organ Failure and Death in Alcoholic Hepatitis
著者:: Michelena, Javier, 等
出版事項: (2015)

Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis
著者:: Javier Michelena, 等
出版事項: (2015)

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
著者:: V. Marin, 等
出版事項: (2017)

A novel mouse model of acute-on-chronic cholestatic alcoholic liver disease: A systems biology comparison with human alcoholic hepatitis
著者:: Furuya, Shinji, 等
出版事項: (2019)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
著者:: Brandl, Katharina, 等
出版事項: (2018)

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
著者:: Katharina Brandl, 等
出版事項: (2018)

Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis
著者:: Gao, Bei, 等
出版事項: (2021)

Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis
著者:: Mohamed Bou Saleh, 等
出版事項: (2021)

Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis
著者:: Lang, Sonja, 等
出版事項: (2019)

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis
著者:: Sonja Lang, 等
出版事項: (2019)

Alcoholic Hepatitis
著者:: Gougol, Amir, 等
出版事項: (2021)

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
著者:: Pau Sancho‐Bru, 等
出版事項: (2012)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
著者:: Aguilar-Bravo, Beatriz, 等
出版事項: (2019)

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
著者:: Beatriz Aguilar‐Bravo, 等
出版事項: (2018)

Loss of liver function in chronic liver disease: An identity crisis
著者:: Carmen Berasain, 等
出版事項: (2022)

Perturbations in mitochondrial dynamics are closely involved in the progression of Alcoholic Liver Disease.
著者:: Palma, Elena, 等
出版事項: (2020)

TLR7‐let‐7 Signaling Contributes to Ethanol‐Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis
著者:: Massey, Veronica L., 等
出版事項: (2018)

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases
著者:: Guldiken, Nurdan, 等
出版事項: (2021)

Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
著者:: Dubuquoy, Laurent, 等
出版事項: (2009)

Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
著者:: Stärkel, Peter, 等
出版事項: (2019)

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
著者:: Odena, Gemma, 等
出版事項: (2016)

Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming
著者:: Beatriz Aguilar‐Bravo, 等
出版事項: (2023)

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH
著者:: Zanieri, Francesca, 等
出版事項: (2020)

Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis
著者:: Morales-Ibanez, Oriol, 等
出版事項: (2015)

Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis
著者:: Rachakonda, Vikrant, 等
出版事項: (2019)

Intestinal virome in patients with alcoholic hepatitis
著者:: Jiang, Lu, 等
出版事項: (2020)

Intestinal Virome in Patients With Alcoholic Hepatitis
著者:: Lu Jiang, 等
出版事項: (2020)

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease
著者:: Ratna, Anuradha, 等
出版事項: (2021)

504. Case SEries: Nasal Antimicrobial Photodisinfection (APDT) as Treatment Protocol for Asymptomatic and Early Stage COVID-19 Patients
著者:: Kolenda, Jack, 等
出版事項: (2021)

Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
著者:: Meritxell Ventura‐Cots, 等
出版事項: (2022)

Alcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder
著者:: Juan Pablo Arab, 等
出版事項: (2023)

Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD
著者:: Edilmar Alvarado‐Tápias, 等
出版事項: (2023)

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems
著者:: Alejandro Soto–Gutiérrez, 等
出版事項: (2017)