Assembling Large Genomes with Single-Molecule Sequencing and Locality Sensitive Hashing
ABSTRACT We report reference-grade de novo assemblies of four model organisms and the human genome from single-molecule, real-time (SMRT) sequencing. Long-read SMRT sequencing is routinely used to finish microbial genomes, but the available assembly methods have not scaled well to larger genomes. He...
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| Auteurs principaux: | , , , , , |
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| Format: | Pré-impressão |
| Langue: | anglais |
| Publié: |
2014
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| Accès en ligne: | https://doi.org/10.1101/008003 |
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