Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-selective EGFR allosteric inhibitor, JBJ-04-125-02, which as a single agent can inhibi...

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Main Authors: Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J.H. De Clercq, Man Xu, Stephen Wang, Michael D. Cameron, David E. Heppner, Bo Hee Shin, Thomas W. Gero, Annan Yang, Suzanne E. Dahlberg, Kwok‐Kin Wong, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
格式: Artigo
语言:英语
出版: 2019
在线阅读:https://doi.org/10.1158/2159-8290.cd-18-0903
https://cancerdiscovery.aacrjournals.org/content/candisc/9/7/926.full.pdf
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