Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-selective EGFR allosteric inhibitor, JBJ-04-125-02, which as a single agent can inhibi...
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| Autors principals: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2019
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| Accés en línia: | https://doi.org/10.1158/2159-8290.cd-18-0903 https://cancerdiscovery.aacrjournals.org/content/candisc/9/7/926.full.pdf |
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