Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-selective EGFR allosteric inhibitor, JBJ-04-125-02, which as a single agent can inhibi...

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Podrobná bibliografie
Hlavní autoři: Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J.H. De Clercq, Man Xu, Stephen Wang, Michael D. Cameron, David E. Heppner, Bo Hee Shin, Thomas W. Gero, Annan Yang, Suzanne E. Dahlberg, Kwok‐Kin Wong, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
Médium: Artigo
Jazyk:angličtina
Vydáno: 2019
On-line přístup:https://doi.org/10.1158/2159-8290.cd-18-0903
https://cancerdiscovery.aacrjournals.org/content/candisc/9/7/926.full.pdf
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Internet

https://doi.org/10.1158/2159-8290.cd-18-0903
https://cancerdiscovery.aacrjournals.org/content/candisc/9/7/926.full.pdf

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