DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the DNA methylome, its fu...

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Main Authors: Hans Binder, Edith Willscher, Henry Loeffler‐Wirth, Lydia Hopp, David Jones, Stefan M. Pfister, Markus Kreuz, Dorothee Gramatzki, Erik Fortenbacher, Bettina Hentschel, Marcos Tatagiba, Ulrich Herrlinger, Hartmut Vatter, Jakob Matschke, Manfred Westphal, Dietmar Krex, Gabriele Schackert, J.-C. Tonn, Uwe Schlegel, Hans‐Jakob Steiger, Wolfgang Wick, Ruthild G. Weber, Michael Weller, Markus Loeffler
Format: Artigo
Jezik:angleščina
Izdano: 2019
Online dostop:https://doi.org/10.1186/s40478-019-0704-8
https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0704-8
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https://doi.org/10.1186/s40478-019-0704-8
https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0704-8

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