Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation
Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common heritable cancer predisposition syndrome caused by germline mutations in the NF1 tumor suppressor, which encodes a GTPase-activating protein...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2019
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| Online Erişim: | https://doi.org/10.1093/hmg/ddz095 |
| Etiketler: |
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