An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
The majority of individuals with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit neuronal cytoplasmic inclusions rich in the RNA binding protein TDP43. Even so, the relation between the RNA binding properties of TDP43 and neurodegeneration remains obscure. Here, we show...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2019
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| Online Access: | https://doi.org/10.1016/j.celrep.2019.03.093 https://www.cell.com/article/S2211124719304322/pdf |
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