An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

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Hlavní autoři: Shan Chung, Nguyễn Văn Hiệp, Yuwen Linda Lin, Julien Lafrance‐Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin B. Tesar, James A. Ernst, Saloumeh K Fischer, Greg A. Lazar, Saileta Prabhu, An Song
Médium: Artigo
Jazyk:angličtina
Vydáno: 2019
On-line přístup:https://doi.org/10.1080/19420862.2019.1605270
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true
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https://doi.org/10.1080/19420862.2019.1605270
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true

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