An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2019
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| Accès en ligne: | https://doi.org/10.1080/19420862.2019.1605270 https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true |
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