An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

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Bibliographic Details
Main Authors: Shan Chung, Nguyễn Văn Hiệp, Yuwen Linda Lin, Julien Lafrance‐Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin B. Tesar, James A. Ernst, Saloumeh K Fischer, Greg A. Lazar, Saileta Prabhu, An Song
Format: Artigo
Language:English
Published: 2019
Online Access:https://doi.org/10.1080/19420862.2019.1605270
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true
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