An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

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Main Authors: Shan Chung, Nguyễn Văn Hiệp, Yuwen Linda Lin, Julien Lafrance‐Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin B. Tesar, James A. Ernst, Saloumeh K Fischer, Greg A. Lazar, Saileta Prabhu, An Song
格式: Artigo
语言:英语
出版: 2019
在线阅读:https://doi.org/10.1080/19420862.2019.1605270
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true
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https://doi.org/10.1080/19420862.2019.1605270
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1605270?needAccess=true

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