A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Abstract Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsi...

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Main Authors: Yilong Zou, Michael J. Palte, Amy Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen‐Yi Tseng, Rebecca Deasy, Maria Kost‐Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
Format: Artigo
Language:English
Published: 2019
Online Access:https://doi.org/10.1038/s41467-019-09277-9
https://www.nature.com/articles/s41467-019-09277-9.pdf
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https://doi.org/10.1038/s41467-019-09277-9
https://www.nature.com/articles/s41467-019-09277-9.pdf

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