MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localize...

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Huvudupphovsmän: Yahui Yan, Cláudia Rato, Lukas Rohland, Steffen Preißler, David Ron
Materialtyp: Artigo
Språk:engelska
Publicerad: 2019
Länkar:https://doi.org/10.1038/s41467-019-08450-4
https://www.nature.com/articles/s41467-019-08450-4.pdf
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