MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localize...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2019
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| Online Access: | https://doi.org/10.1038/s41467-019-08450-4 https://www.nature.com/articles/s41467-019-08450-4.pdf |
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