Prostaglandin E<sub>2</sub> inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca<sup>2+</sup> signaling
We have shown that calcium (Ca2+) oscillations in human pulmonary fibroblasts (HPFs) contribute to profibrotic effects of transforming growth factor-β (TGF-β) and that disruption of these oscillations blunts features of pulmonary fibrosis. Prostaglandin E2 (PGE2) exerts antifibrotic effects in the l...
Shranjeno v:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | angleščina |
| Izdano: |
2019
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| Online dostop: | https://doi.org/10.1152/ajplung.00403.2018 https://journals.physiology.org/doi/pdf/10.1152/ajplung.00403.2018 |
| Oznake: |
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