The herpesviral antagonist m152 reveals differential activation of <scp>STING</scp> ‐dependent <scp>IRF</scp> and <scp>NF</scp> ‐κB signaling and <scp>STING</scp> 's dual role during <scp>MCMV</scp> infection

The herpesviral antagonist m152 reveals differential activation of <scp>STING</scp> ‐dependent <scp>IRF</scp> and <scp>NF</scp> ‐κB signaling and <scp>STING</scp> 's dual role during <scp>MCMV</scp> infection

Cytomegaloviruses (CMVs) are master manipulators of the host immune response. Here, we reveal that the murine CMV (MCMV) protein m152 specifically targets the type I interferon (IFN) response by binding to stimulator of interferon genes (STING), thereby delaying its trafficking to the Golgi compartm...

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Bibliografiska uppgifter
Huvudupphovsmän: Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R. Paludan, Nadia Füllbrunn, Niels A. W. Lemmermann, Melanie M. Brinkmann
Materialtyp: Artigo
Språk:engelska
Publicerad: 2019
Länkar:https://doi.org/10.15252/embj.2018100983
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https://doi.org/10.15252/embj.2018100983

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