Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation

Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation

Highlights•A-to-I RNA editing alters cell-cycle transit by impairing pri-miR-26a maturation•Enforced miR-26a expression reduces BC CML progenitor propagation in vivo•pri-miR-155 downregulation by ADAR1 stabilizes MDM2 in CML progenitors•Hyper-editing of 3′ UTR of MDM2 prevents miR-155 binding in CML...

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Hoofdauteurs: Qingfei Jiang, Jane Isquith, M Zipeto, Raymond Diep, Jessica Pham, Nathaniel P. Delos Santos, Eduardo Reynoso, Julisia Chau, Heather Leu, Elisa Lazzari, Etienne Melese, Wenxue Ma, Rongxin Fang, Mark D. Minden, Sheldon Morris, Bing Ren, Gabriel Pineda, Frida Holm, Catriona Jamieson
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2019
Online toegang:https://doi.org/10.1016/j.ccell.2018.11.017
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https://doi.org/10.1016/j.ccell.2018.11.017

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