Targeting the CALR interactome in myeloproliferative neoplasms

Targeting the CALR interactome in myeloproliferative neoplasms

Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompletely defined. We used m...

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Hlavní autoři: Elodie Pronier, Paolo Cifani, Tiffany R. Merlinsky, Katharine Barr Berman, Amritha Varshini Hanasoge Somasundara, Raajit K. Rampal, John LaCava, Karen E. Wei, Friederike Pastore, Jesper L.V. Mååg, Jane Park, Richard P. Koche, Alex Kentsis, Ross L. Levine
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf
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https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf

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