Targeting the CALR interactome in myeloproliferative neoplasms

Targeting the CALR interactome in myeloproliferative neoplasms

Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompletely defined. We used m...

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Detalhes bibliográficos
Principais autores: Elodie Pronier, Paolo Cifani, Tiffany R. Merlinsky, Katharine Barr Berman, Amritha Varshini Hanasoge Somasundara, Raajit K. Rampal, John LaCava, Karen E. Wei, Friederike Pastore, Jesper L.V. Mååg, Jane Park, Richard P. Koche, Alex Kentsis, Ross L. Levine
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Acesso em linha:https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf
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Internet

https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf

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