Targeting the CALR interactome in myeloproliferative neoplasms

Targeting the CALR interactome in myeloproliferative neoplasms

Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompletely defined. We used m...

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Xehetasun bibliografikoak
Egile Nagusiak: Elodie Pronier, Paolo Cifani, Tiffany R. Merlinsky, Katharine Barr Berman, Amritha Varshini Hanasoge Somasundara, Raajit K. Rampal, John LaCava, Karen E. Wei, Friederike Pastore, Jesper L.V. Mååg, Jane Park, Richard P. Koche, Alex Kentsis, Ross L. Levine
Formatua: Artigo
Hizkuntza:ingelesa
Argitaratua: 2018
Sarrera elektronikoa:https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf
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https://doi.org/10.1172/jci.insight.122703
http://insight.jci.org/articles/view/122703/files/pdf

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