Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) a...

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Detalhes bibliográficos
Main Authors: Shuhei Asada, Susumu Goyama, Daichi Inoue, Shiori Shikata, Reina Takeda, Tsuyoshi Fukushima, Taishi Yonezawa, Takeshi Fujino, Yasutaka Hayashi, Kimihito C. Kawabata, Tomofusa Fukuyama, Yosuke Tanaka, Akihiko Yokoyama, Satoshi Yamazaki, Hiroko Kozuka‐Hata, Masaaki Oyama, Shinya Kojima, Masahito Kawazu, Hiroyuki Mano, Toshio Kitamura
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Acesso em linha:https://doi.org/10.1038/s41467-018-05085-9
https://www.nature.com/articles/s41467-018-05085-9.pdf
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Internet

https://doi.org/10.1038/s41467-018-05085-9
https://www.nature.com/articles/s41467-018-05085-9.pdf

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