Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H ( <i>CFH</i> ) gene family

Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H ( <i>CFH</i> ) gene family

Significance Genetic variation of the complement factor H ( CFH ) gene family is associated with several complex diseases. Here, we have performed both long- and short-read sequencing of multiple humans and nonhuman primates in an effort to understand its complex evolutionary history. We find that t...

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Библиографические подробности
Главные авторы: Stuart Cantsilieris, Bradley J. Nelson, John Huddleston, Carl Baker, Lana Harshman, Kelsi Penewit, Katherine M. Munson, Melanie Sorensen, AnneMarie E. Welch, Vy Dang, Felix Graßmann, Andrea J. Richardson, Robyn H. Guymer, Tina A. Graves-Lindsay, Richard K. Wilson, Bernhard H. F. Weber, Paul N. Baird, Rando Allikmets, Evan E. Eichler
Формат: Artigo
Язык:английский
Опубликовано: 2018
Online-ссылка:https://doi.org/10.1073/pnas.1717600115
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https://doi.org/10.1073/pnas.1717600115

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