Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...

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Opis bibliograficzny
Główni autorzy: Reina Nagase, Daichi Inoue, Alessandro Pastore, Takeshi Fujino, Hsin‐An Hou, Norimasa Yamasaki, Susumu Goyama, Makoto Saika, Akinori Kanai, Yasuyuki Sera, Sayuri Horikawa, Yasunori Ota, Shuhei Asada, Yasutaka Hayashi, Kimihito C. Kawabata, Reina Takeda, Hwei‐Fang Tien, Hiroaki Honda, Omar Abdel‐Wahab, Toshio Kitamura
Format: Artigo
Język:angielski
Wydane: 2018
Dostęp online:https://doi.org/10.1084/jem.20171151
https://rupress.org/jem/article-pdf/215/6/1729/1169496/jem_20171151.pdf
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https://doi.org/10.1084/jem.20171151
https://rupress.org/jem/article-pdf/215/6/1729/1169496/jem_20171151.pdf

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