The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes
ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2018
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| Online Access: | https://doi.org/10.1128/mbio.00089-18 |
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