The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes

ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sabine Pellett, Marite Bradshaw, William H. Tepp, Christina L. Pier, Regina C. M. Whitemarsh, Chen Chen, Joseph Barbieri, Eric A. Johnson
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2018
Mynediad Ar-lein:https://doi.org/10.1128/mbio.00089-18
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