Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis

Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis

Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia....

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Hlavní autoři: Dragana Dragoljevic, Michael J. Kraakman, Prabhakara R. Nagareddy, Devi Ngo, Waled Shihata, Hélène L. Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al‐Sharea, Gerard Pernes, Michelle Flynn, Graeme I. Lancaster, Mark A. Febbraio, Jaye Chin‐Dusting, Beatriz Y. Hanaoka, Ian P. Wicks, Andrew Murphy
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1093/eurheartj/ehy119
https://academic.oup.com/eurheartj/article-pdf/39/23/2158/25041461/ehy119.pdf
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https://doi.org/10.1093/eurheartj/ehy119
https://academic.oup.com/eurheartj/article-pdf/39/23/2158/25041461/ehy119.pdf

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