Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation wi...

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Main Authors: Taeko Kimura, Govinda Sharma, Koichi Ishiguro, Shin‐ichi Hisanaga
Format: Revisão
Jezik:angleščina
Izdano: 2018
Online dostop:https://doi.org/10.3389/fnins.2018.00044
https://www.frontiersin.org/articles/10.3389/fnins.2018.00044/pdf
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