Genetic and epigenetic factors which modulate differentiation propensity in human pluripotent stem cells

Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer or cell type over others. Chromosomal aberrations, mitochondrial mutations, genetic diversity and epigeneti...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Alexander Keller, Dominika Dziedzicka, Filippo Zambelli, Christina Markouli, Karen Sermon, Claudia Spits, Mieke Geens
Hōputu: Artigo
Reo:Ingarihi
I whakaputaina: 2017
Urunga tuihono:https://doi.org/10.1093/humupd/dmx042
https://academic.oup.com/humupd/article-pdf/24/2/162/24149710/dmx042.pdf
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