Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Selective irreversible inhibitors of selenoprotein TXNRD1 yield anticancer efficacy without overt systemic toxicity in mouse models.

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Detalles Bibliográficos
Main Authors:	William C. Stafford, Xiaoxiao Peng, Maria Hägg Olofsson, Xiaonan Zhang, Diane K. Luci, Frank Leigh Lu, Qing Cheng, L. Tresaugues, Thomas S. Dexheimer, Nathan P. Coussens, Martin Augsten, Hanna-Stina Martinsson Ahlzén, Owe Orwar, Arne Östman, Sharon Stone‐Elander, David J. Maloney, Ajit Jadhav, Anton Simeonov, Stig Linder, Elias S.J. Arnér
Formato:	Artigo
Idioma:	inglés
Publicado:	2018
Acceso en liña:	https://doi.org/10.1126/scitranslmed.aaf7444
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