Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the underlying causal variants are shared between ancestry groups. However, heterogeneity in allelic effects between GWAS at these loci can occur that...

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Príomhchruthaitheoirí: Reedik Mägi, Momoko Horikoshi, Tamar Sofer, Anubha Mahajan, Hidetoshi Kitajima, Nora Franceschini, Mark I. McCarthy, Andrew P. Morris
Formáid: Revisão
Teanga:Béarla
Foilsithe / Cruthaithe: 2017
Rochtain ar líne:https://doi.org/10.1093/hmg/ddx280
https://academic.oup.com/hmg/article-pdf/26/18/3639/24646976/ddx280.pdf
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