Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease
Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F-actin accompanied by increased globular...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Acesso em linha: | https://doi.org/10.1523/jneurosci.2127-17.2017 https://www.jneurosci.org/content/jneuro/38/5/1085.full.pdf |
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