Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes
Antisense oligonucleotide (ASO) therapeutics show tremendous promise for the treatment of previously intractable human diseases but to exert their effects on cellular RNA processing they must first cross the plasma membrane by endocytosis. The conjugation of ASOs to a receptor ligand can dramaticall...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | inglés |
| Publicado: |
2017
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| Acceso en liña: | https://doi.org/10.1093/nar/gkx960 https://academic.oup.com/nar/article-pdf/45/21/12388/22146518/gkx960.pdf |
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