Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Significance Understanding the genetic basis of human disease can reveal mechanisms of disease pathology and guide the design of novel treatment strategies. Here, we leverage insights from genetic studies to create a blueprint for treatment of inflammatory bowel disease (IBD). We demonstrate the fea...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Elizaveta S. Leshchiner, Jason S. Rush, Michael A. Durney, Zhifang Cao, Vlado Dančík, Benjamin Chittick, Huixian Wu, Adam Petrone, Joshua A. Bittker, Andrew J. Phillips, José R. Perez, Alykhan F. Shamji, Virendar K. Kaushik, Mark J. Daly, Daniel B. Graham, Stuart L. Schreiber, Ramnik J. Xavier
Formatua: Artigo
Hizkuntza:ingelesa
Argitaratua: 2017
Sarrera elektronikoa:https://doi.org/10.1073/pnas.1705748114
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Internet

https://doi.org/10.1073/pnas.1705748114

Antzeko izenburuak