Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and Dysfunction
The apelin pathway has emerged as a critical regulator of cardiovascular homeostasis and disease. However, the exact role of pyr1-apelin-13 in angiotensin (Ang) II–mediated heart disease remains unclear. We used apelin-deficient (APLN −/y ) and apolipoprotein E knockout mice to evaluate the regulato...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2017
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| Accès en ligne: | https://doi.org/10.1161/hypertensionaha.117.10156 |
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