Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies
Abstract FMS-like tyrosine kinase-3 (FLT3) tyrosine kinase inhibitors (TKI) have been tested extensively to limited benefit in acute myeloid leukemia (AML). We hypothesized that FLT3/internal tandem duplication (ITD) leukemia cells exhibit mechanisms of intrinsic signaling adaptation to TKI treatmen...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2017
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| Online Access: | https://doi.org/10.1158/0008-5472.can-16-2593 https://cancerres.aacrjournals.org/content/canres/77/20/5554.full.pdf |
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