Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation

Objective— Oxidative stress and inflammation play key roles in the development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted in response to oxidative stress and promotes inflammation and cardiovascular disease. Endothelial cell (EC) dysfunction is an early event in the p...

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Main Authors: Chao Xue, Mark P. Sowden, Bradford C. Berk
格式: Artigo
语言:英语
出版: 2017
在线阅读:https://doi.org/10.1161/atvbaha.117.309212
https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.117.309212
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