Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation
Objective— Oxidative stress and inflammation play key roles in the development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted in response to oxidative stress and promotes inflammation and cardiovascular disease. Endothelial cell (EC) dysfunction is an early event in the p...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | angielski |
| Wydane: |
2017
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| Dostęp online: | https://doi.org/10.1161/atvbaha.117.309212 https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.117.309212 |
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