SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation

The inhalation of silica dust is associated with fibrosis and lung cancer, which are triggered by macrophage inflammatory responses; however, how macrophages recognize silica remains largely unknown. Here, we identify by functional expression cloning the class B scavenger receptor SR-B1 as a silica...

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Main Authors: Misato Tsugita, Nobuyuki Morimoto, Manabu Tashiro, Kengo Kinoshita, M. NAKAYAMA
Formato: Artigo
Idioma:inglés
Publicado: 2017
Acceso en liña:https://doi.org/10.1016/j.celrep.2017.01.004
https://www.cell.com/article/S2211124717300220/pdf
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