Multivalent Rab interactions determine tether-mediated membrane fusion
Membrane fusion at endomembranes requires cross-talk between Rab GTPases and tethers to drive SNARE-mediated lipid bilayer mixing. Several tethers have multiple Rab-binding sites with largely untested function. Here we dissected the lysosomal HOPS complex as a tethering complex with just two binding...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | English |
| Published: |
2016
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| Online Access: | https://doi.org/10.1091/mbc.e16-11-0764 |
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